Jamestown Canyon Virus Seroprevalence in Endemic Regions and Implications for Diagnostic Testing
Estimated Jamestown Canyon virus seroprevalence, including for IgM antibodies, is elevated in endemic areas, complicating the interpretation of serologic testing in diagnosing acute disease in symptomatic individuals. Diagnosing Jamestown Canyon virus disease requires a high degree of clinical suspicion, ruling out other possible causes of illness, and if possible, collecting acute and convalescent samples. New assays to detect acute infection could improve diagnosis and public health surveillance for Jamestown Canyon virus disease.
Authors
- Matthew Osborne (ORCID: https://orcid.org/0000-0001-5217-0392)
- Catherine Brown (ORCID: https://orcid.org/0000-0002-9394-8516)
- Elizabeth Schiffman (ORCID: https://orcid.org/0000-0001-5153-7471)
- Kacie Grimm
- Xia Lee (ORCID: https://orcid.org/0000-0001-9248-3940)
- Brandi Hopkins
- Brad J. Biggerstaff (ORCID: https://orcid.org/0000-0002-3105-3530)
- Sridhar V. Basavaraju (ORCID: https://orcid.org/0000-0002-8376-0499)
- Jennifer Lehman (ORCID: https://orcid.org/0000-0001-7114-208X)
- Rebecca Osborn (ORCID: https://orcid.org/0009-0004-1079-3558)
- Paula Saá (ORCID: https://orcid.org/0000-0001-6077-4532)
- Eric C. Mossel (ORCID: https://orcid.org/0000-0002-2315-4577)
- Aaron C. Brault (ORCID: https://orcid.org/0000-0001-5801-3021)
- David E. Krysztof (ORCID: https://orcid.org/0000-0003-4926-4675)
- Amanda E. Calvert (ORCID: https://orcid.org/0000-0002-8237-2654)
- Rebecca Townsend
- Susan L. Stramer (ORCID: https://orcid.org/0000-0002-5865-6366)
- Stacey W. Martin (ORCID: https://orcid.org/0000-0003-1767-6042)
- Elisa Thrasher
- J. Erin Staples (ORCID: https://orcid.org/0000-0002-1446-4071)
- Carolyn V. Gould (ORCID: https://orcid.org/0000-0002-8216-0803)
- Rebekah Sutter (ORCID: https://orcid.org/0009-0006-6695-7421)
Institutions
- Wisconsin Department of Health Services (US)
- Centers for Disease Control and Prevention (US)
- Massachusetts Department of Public Health (US)
- American Red Cross (US)
- University of the Potomac (US)
- Epidemic Intelligence Service (US)
- Minnesota Department of Health (US)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1093/cid/ciaf131
- Citations
- 2
- Primary Topic
- Viral Infections and Vectors
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- U.S. Department of Energy
- Oak Ridge Institute for Science and Education