Metabolomic Pathways of Inflammation and Mitochondrial Dysfunction Are Related to Worsening Healthy Aging Index and Mortality
A multiorgan healthy aging phenotype was linked to lipid metabolites, suggesting potential pathways related to mitochondrial function, oxidative stress, and inflammation. Metabolomics of HAI at older age were related to worsening health and mortality, suggesting potential links between metabolism and accelerated physiological aging.
Authors
- Ravi V. Shah (ORCID: https://orcid.org/0000-0002-4471-7156)
- Eleanor L. Watts (ORCID: https://orcid.org/0000-0001-9229-2589)
- Megan M. Marron (ORCID: https://orcid.org/0000-0001-9561-3966)
- Clary B. Clish (ORCID: https://orcid.org/0000-0001-8259-9245)
- Qu Tian (ORCID: https://orcid.org/0000-0003-2706-1439)
- Shanshan Yao (ORCID: https://orcid.org/0000-0002-2125-1242)
- Anne B. Newman (ORCID: https://orcid.org/0000-0002-0106-1150)
- Venkatesh Locharla Murthy (ORCID: https://orcid.org/0000-0002-7901-1321)
Institutions
- Broad Institute (US)
- National Institutes of Health (US)
- University of Pittsburgh (US)
- University of Michigan (US)
- National Institute on Aging (US)
- National Cancer Institute (US)
- Institute of Aging (CA)
- Department of Health and Human Services (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- The Journals of Gerontology Series A
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1093/gerona/glaf057
- Citations
- 4
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 4.66