Network pharmacology approach to unveiling the mechanism of berberine in the amelioration of morphine tolerance.
BBR, a key component of HLD, effectively suppressed microglial activation and neuro-inflammation by regulating the NF-κB and apoptosis signaling pathways, thereby delaying MT. This study offers a novel approach to enhance the clinical analgesic efficacy of morphine.
Authors
- Shi Jianwen
- Shuai Han (ORCID: https://orcid.org/0000-0002-5963-3772)
- Ge Yali
- Zirui Wang (ORCID: https://orcid.org/0000-0003-0626-742X)
- Ju Gao (ORCID: https://orcid.org/0000-0002-0837-2365)
- Du Zhikang
- Huang Tianfeng
Institutions
- Northern Jiangsu People's Hospital (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-04-01
- DOI
- https://doi.org/10.19852/j.cnki.jtcm.2025.02.012
- Citations
- 2
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 2.79