Hypolipidemic effect and mechanism of Hedan tablet based on network pharmacology.
The mechanism by which HDT treats hyperlipidemia involves modification of the lipid metabolism targets such as downregulating SREBF2, HMGCR and MMP9, and upregulating PPAR-α and PPAR-γ, as well as anti-inflammatory and antioxidant actions. This study provides a pharmacological and biological rationale for the use of HDT in clinical hyperlipidemia management.
Authors
- Can Cui (ORCID: https://orcid.org/0000-0003-1139-0182)
- Yaqi Wang (ORCID: https://orcid.org/0000-0002-0298-2955)
- Huiming Huang (ORCID: https://orcid.org/0000-0003-0797-7845)
- Zhu Yanchen
- Xuecheng Wang (ORCID: https://orcid.org/0000-0001-6643-407X)
- Shao Feng
- Weng Jiajun
- Tang Fangrui
- Fan Shengxian
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Peking University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-04-01
- DOI
- https://doi.org/10.19852/j.cnki.jtcm.2025.02.015
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00