Trans-omics landscape of systemic vasculitis identified matrix metalloproteinase 12 as a novel signature molecule
MMP12 is a disease-specific molecule that is associated with macrophage maturation and the formation of multinucleated giant cells and reflects disease activity independently of the IL-6 pathway in systemic vasculitis.
Authors
- Mariko Noguchi-Sasaki
- Masaki Yazawa (ORCID: https://orcid.org/0000-0002-2446-2766)
- Sota Yamada (ORCID: https://orcid.org/0000-0002-5083-5650)
- Hideyuki Shimizu (ORCID: https://orcid.org/0000-0003-0298-4261)
- Kenjiro Hanaoka (ORCID: https://orcid.org/0000-0003-0797-4038)
- Mayu Magi
- Junko Kuramoto (ORCID: https://orcid.org/0000-0003-3430-5710)
- Yoshihiro Matsumoto (ORCID: https://orcid.org/0000-0001-6580-7188)
- Tatsuya Kato (ORCID: https://orcid.org/0000-0001-7990-2557)
- Masaru Takeshita (ORCID: https://orcid.org/0000-0002-3281-6595)
- Shinichi Onishi (ORCID: https://orcid.org/0000-0003-1465-6206)
- Tsutomu Takeuchi (ORCID: https://orcid.org/0000-0003-1111-8218)
- Kotaro Matsumoto (ORCID: https://orcid.org/0000-0003-2047-7626)
- Yuko Kaneko (ORCID: https://orcid.org/0000-0003-2646-5765)
- Eita Sasaki (ORCID: https://orcid.org/0000-0002-8202-4465)
- Katsuya Suzuki
- Tsutomu Ito
- Hiroto Yoshida (ORCID: https://orcid.org/0009-0001-5111-0125)
Institutions
- Keio University (JP)
- Chugai Pharma (United States) (US)
- Saitama Medical University (JP)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1093/rheumatology/keaf175
- Citations
- 2
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 3.04