Long-term alveolar-capillary diffusion impairments after severe SARS-CoV-2 pneumonia
Both DLCO determinants were affected, with vascular impairment predominating. Vc reduction was present in most patients, with mean values below the lower limit of normality, whereas DmCO was less affected and often normal. The elevated DLNO/DLCO ratio suggests that persistent DLCO reduction is primarily driven by prolonged pulmonary capillary circulation dysfunction rather than alveolar membrane alterations, highlighting the vascular component as the primary site of long-term impairment.
Authors
- Andrea Borghesi (ORCID: https://orcid.org/0000-0002-4761-2923)
- María Lorenza Muiesan (ORCID: https://orcid.org/0000-0002-4007-9441)
- Deodato Assanelli (ORCID: https://orcid.org/0000-0002-0286-9493)
- Nicola Latronico (ORCID: https://orcid.org/0000-0002-2521-5871)
- Roberto Maroldi (ORCID: https://orcid.org/0000-0001-5664-353X)
- Claudio Tantucci (ORCID: https://orcid.org/0000-0002-1185-9465)
- Simone Piva (ORCID: https://orcid.org/0000-0002-5483-8007)
- Gabriele Tomasoni
- Bruno Guarneri
- Laura Pini (ORCID: https://orcid.org/0000-0001-6563-4942)
- Elena Peli
- Dina Visca (ORCID: https://orcid.org/0000-0003-2298-1623)
- Francesca Zubani
- Yehia El Masri
- Michele Guerini
- Jordan Giordani (ORCID: https://orcid.org/0000-0002-5958-0228)
- Sergio Cattaneo (ORCID: https://orcid.org/0000-0001-8313-508X)
- Alessandro Pini (ORCID: https://orcid.org/0000-0002-8325-6057)
- Guido Levi (ORCID: https://orcid.org/0000-0002-7163-2270)
- Silvia Stella Barbieri (ORCID: https://orcid.org/0000-0002-7486-2637)
- Alberto Giannini
- Stefano Piras
- Manuela Violini
- Silvia Capuccini
- Irene Palazzi
Institutions
- University of Insubria (IT)
- Istituti Clinici Scientifici Maugeri (IT)
- Surgical Specialties (Canada) (CA)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- University of Brescia (IT)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1080/07853890.2025.2483383
- Citations
- 4
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 5.56