Pharmacokinetic approaches to standardize antiviral exposure in cerebrospinal fluid
PK modeling successfully standardized ARV CSF concentrations to a given time point (i.e., C<sub>MAX</sub> or C<sub>Trough</sub>) to allow estimation of CSF penetration. This approach provides uniformity for the assessment of exposure, for the estimation of whether desired therapeutic drug goals are obtained in the CSF, and for further studies to investigate whether CSF exposure metrics calculated using this method are associated with measures of HIV persistence.
Authors
- Anthony T. Podany (ORCID: https://orcid.org/0000-0002-8371-0379)
- Ying Mu
- Courtney Vail Fletcher (ORCID: https://orcid.org/0000-0002-3703-7849)
- Joseph J. Eron (ORCID: https://orcid.org/0000-0002-4938-0644)
- Deborah K. McMahon (ORCID: https://orcid.org/0000-0002-4374-3539)
- Jiajun Liu (ORCID: https://orcid.org/0000-0002-4330-2098)
- Ronald J. Bosch (ORCID: https://orcid.org/0000-0002-1774-4140)
- John W. Mellors (ORCID: https://orcid.org/0000-0002-3737-9742)
- Rajesh T. Gandhi (ORCID: https://orcid.org/0000-0002-9701-6062)
- Sean N. Avedissian (ORCID: https://orcid.org/0000-0002-0935-6455)
- Serena Spudich (ORCID: https://orcid.org/0000-0001-6032-3950)
- Caitlyn McCarthy
Institutions
- University of North Carolina at Chapel Hill (US)
- United States Food and Drug Administration (US)
- Harvard University (US)
- University of Pittsburgh (US)
- Yale University (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1002/phar.70013
- Primary Topic
- Infectious Encephalopathies and Encephalitis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AIDS Clinical Trials Group
- Harvard University Center for AIDS Research
- National Institute of Mental Health
- National Institute of Allergy and Infectious Diseases