Pairwise analysis of plasma cell-free DNA before and after palliative second-line paclitaxel plus ramucirumab treatment in patients with metastatic gastric cancer
Although cfDNA alone cannot replace ttDNA entirely, cfDNA analysis revealed additional mutations. Notably, PD-cfDNA analysis revealed novel pathogenic mutations that emerged during treatment. Moreover, the baseline circulating tumor DNA fraction concentration and VAF values were associated with longer PFS.
Authors
- Eun Hee Jung (ORCID: https://orcid.org/0000-0002-3057-4502)
- Koung Jin Suh (ORCID: https://orcid.org/0000-0002-1881-8738)
- Dong Soo Kyung (ORCID: https://orcid.org/0000-0003-2910-0120)
- Min-Su Kang (ORCID: https://orcid.org/0000-0001-6491-2277)
- Yu Jung Kim (ORCID: https://orcid.org/0000-0002-5037-0523)
- Jeongmin Seo (ORCID: https://orcid.org/0000-0002-1018-9009)
- Se Hyun Kim (ORCID: https://orcid.org/0000-0002-2292-906X)
- Kui‐Jin Kim (ORCID: https://orcid.org/0000-0001-7715-5121)
- Keun‐Wook Lee (ORCID: https://orcid.org/0000-0002-8491-703X)
- Jee Hyun Kim (ORCID: https://orcid.org/0000-0003-1336-3620)
- Jin Won Kim (ORCID: https://orcid.org/0000-0002-1357-7015)
- Sung‐Hyun Hwang (ORCID: https://orcid.org/0000-0003-2413-5287)
- Ju Hyun Lee
- Hwang‐Phill Kim
- Ji‐Won Kim (ORCID: https://orcid.org/0009-0006-5905-1883)
- Won Yeong Ko
Institutions
- Korea Gas Corporation (South Korea) (KR)
- Seoul National University Bundang Hospital (KR)
- Hankuk University of Foreign Studies (KR)
Publication Details
- Journal
- Gastric Cancer
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1007/s10120-025-01604-y
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Seoul National University Bundang Hospital
- Seoul National University Hospital