Artemether-Lumefantrine Treatment Selects <i>Plasmodium falciparum</i> Multidrug Resistance 1 (<i>pfmdr1</i>) Increased Copy Number Among African Malaria Infections
Our study suggests pfmdr1×N as a marker of P. falciparum in vivo response to lumefantrine in Africa, while indicating patients carrying infections with a pretreatment pfmdr1×N score ≥1.4 before treatment are a group experiencing decreased artemether-lumefantrine performance.
Authors
- José Pedro Gil (ORCID: https://orcid.org/0000-0002-6107-9379)
- Cláudia Fançony (ORCID: https://orcid.org/0000-0003-4421-1769)
- Leyre Pernaute-Lau (ORCID: https://orcid.org/0000-0002-7767-966X)
- Anna Färnert (ORCID: https://orcid.org/0000-0001-7583-282X)
- Edite Rosário (ORCID: https://orcid.org/0000-0002-0419-6181)
- Taís Nóbrega de Sousa (ORCID: https://orcid.org/0000-0002-6874-9427)
- Elsa Fortes-Gabriel (ORCID: https://orcid.org/0000-0002-9378-3643)
- Luís Bernardino (ORCID: https://orcid.org/0000-0003-0294-3152)
- Ioanna Broumou (ORCID: https://orcid.org/0000-0003-2376-3820)
- A. Martins (ORCID: https://orcid.org/0000-0002-1249-8622)
- José M Domingos
- Estevão Sassoma
- Fernando Kuatoko
- Félix Zage
- Evangelia Alexiou
- Jorge Panzo
- Esperança J António
- Mario S Cristovão
Institutions
- Karolinska University Hospital (SE)
- Community Hospital of San Bernardino (US)
- Karolinska Institutet (SE)
- Agostinho Neto University (AO)
- London School of Hygiene & Tropical Medicine (GB)
- Fundação Saúde (BR)
- Hospital Militar Central (CO)
- Instituto Superior Politécnico Metropolitano de Angola (AO)
- Instituto de Saúde (BR)
- Escola Nacional de Saúde Pública (BR)
- Instituto Nacional de Saúde (MZ)
- Ministério da Saúde (ST)
- Discovery Communications (United States) (US)
- Instituto de Investigação Científica Tropical (PT)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1093/infdis/jiaf155
- Citations
- 4
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 7.51