Alcohol and aging: Next‐generation epigenetic clocks predict biological age acceleration in individuals with alcohol use disorder
Overall, we observed moderately improved performance of GrimAge V2 compared with GrimAge V1 with the majority of the parameters tested. The causality-enriched epigenetic clocks lacked significant associations but demonstrate the complexities of aging and inspire further research of AUD and drinking dynamics.
Authors
- Josephin Wagner (ORCID: https://orcid.org/0000-0002-8880-5721)
- A Wagner
- Jeesun Jung (ORCID: https://orcid.org/0000-0002-2668-5541)
- Theodore Perlstein
- Daniel B. Rosoff (ORCID: https://orcid.org/0000-0002-5718-7668)
- Falk W. Lohoff (ORCID: https://orcid.org/0000-0002-0480-7755)
- Joshua Reitz (ORCID: https://orcid.org/0009-0005-1041-6602)
Institutions
- National Institutes of Health (US)
- University of Oxford (GB)
- National Institute on Alcohol Abuse and Alcoholism (US)
Publication Details
- Journal
- Alcohol Clinical and Experimental Research
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1111/acer.70020
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61