Systematically investigate the mechanism underlying the therapeutic effect of emodin in treatment of prostate cancer
Emodin and TP53 have the best binding and stable conformation among core genes. Emodin exhibits a significant inhibitory effect on PC-3 cells at concentration 0.4 ~ 1.6 μmol/L. It showed that anti-prostate cancer properties by regulating cancer and 1L-17 signaling pathway through up-regulating the expressions of CASP3, PPARG genes/proteins, down-regulating IL1B, TP53, TNF, MYC genes/proteins.
Authors
- Jingxin Mao (ORCID: https://orcid.org/0000-0002-2813-1702)
- Yuan Gang (ORCID: https://orcid.org/0000-0001-9432-2411)
- Zheng Li (ORCID: https://orcid.org/0000-0001-6024-0194)
Institutions
- Chongqing University (CN)
- Renji Hospital (CN)
- Chongqing Jiulongpo People's Hospital (CN)
- Chongqing Medical and Pharmaceutical College (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1007/s12672-025-02141-x
- Primary Topic
- Phytochemistry and biological activity of medicinal plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00