Determinants of intellectual and developmental outcomes in a multicenter pediatric hemispherotomy cohort
Age at epilepsy onset, underlying etiology, presence of bilateral structural brain abnormalities, and postsurgical ASM management were key determinants of intellectual and developmental outcomes following hemispherotomy. These findings underscore the importance of timely ASM discontinuation as the only modifiable factor that may optimize intellectual and developmental trajectories. Although direct presurgical comparisons were not possible, the observed associations provide valuable insights into factors influencing cognitive outcomes.
Authors
- Judith Helen Cross (ORCID: https://orcid.org/0000-0001-7345-4829)
- Martin Tisdall (ORCID: https://orcid.org/0000-0001-8880-8386)
- Willem M. Otte (ORCID: https://orcid.org/0000-0003-1511-6834)
- Sarah Ferrand‐Sorbets (ORCID: https://orcid.org/0000-0002-0830-3730)
- Pieter van Eijsden (ORCID: https://orcid.org/0000-0002-8935-140X)
- Georgia Ramantani (ORCID: https://orcid.org/0000-0002-7931-2327)
- Isabelle Jambaqué
- Dorottya Cserpán (ORCID: https://orcid.org/0000-0002-7538-1931)
- Kees P. J. Braun (ORCID: https://orcid.org/0000-0003-3631-0003)
- Christine Bulteau
- Josef Zentner (ORCID: https://orcid.org/0000-0003-0844-9454)
- Monique van Schooneveld
- Gitta Reuner (ORCID: https://orcid.org/0000-0002-9316-3129)
- Niklaus Krayenbühl (ORCID: https://orcid.org/0000-0003-1089-221X)
- Georg Dorfmüller (ORCID: https://orcid.org/0000-0001-7168-1753)
Institutions
- National Health Service (GB)
- University of Freiburg (DE)
- Utrecht University (NL)
- University of Zurich (CH)
- Université Paris Cité (FR)
- Heidelberg University (DE)
- Great Ormond Street Hospital for Children NHS Foundation Trust (GB)
- University Medical Center Freiburg (DE)
- University Medical Center Utrecht (NL)
- National Institute for Health and Care Research (GB)
- Heidelberg University of Education (DE)
- Laboratoire Mémoire et Cognition (FR)
- Fondation de Rothschild (FR)
- University Children's Hospital Zurich (CH)
- University College London (GB)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1111/epi.18391
- Citations
- 2
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Deutsche Forschungsgemeinschaft
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung