Mechanism of Huayu Qutan recipe anti-atherosclerosis mediates lipophagymammalian target of rapamycin complex 1/ transcription factor EB signaling pathway in ApoE-/-mice.
The results indicate that HYQT is an effective traditional Chinese herbal remedy for the treatment of AS. HYQT mitigates macrophage-derived foam cell formation by activating autophagy in atherosclerosis. The mTOR/TFEB signaling pathway and ABCA1 are therapeutic targets of HYQT for the treatment of AS.
Authors
- Ming-Hua Nan
- Pan Jia-xiang
- Guanlin Yang (ORCID: https://orcid.org/0000-0001-6652-0680)
- Lianqun Jia (ORCID: https://orcid.org/0000-0003-0923-6987)
- Pang Lin-lin
- Yue Liu (ORCID: https://orcid.org/0000-0002-2700-922X)
- Dongdong Yuan
- Lihong Gong (ORCID: https://orcid.org/0000-0002-1939-9969)
- Jiajia Yan
- Gao Xiaoyu
- W U Xize
- Min Dongyu
- Cheng Meijia
Institutions
- Liaoning University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (CN)
- China Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-04-01
- DOI
- https://doi.org/10.19852/j.cnki.jtcm.2025.02.016
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00