ESG‐1‐60 and ESG‐1‐61: Novel dopamine D<sub>3</sub> receptor‐preferring partial agonists/antagonists that inhibit cocaine taking and seeking in rodents
Novel D<sub>3</sub> receptor-preferring compounds ESG-1-60 and ESG-1-61 were highly effective in reducing cocaine-taking and cocaine-seeking, under various reinforcement conditions. ESG-1-60 warrants further investigation as a new pharmacotherapy for treating cocaine use disorder as it is effective in these models and lacks unwanted behavioural effects.
Authors
- Omar Soler‐Cedeño (ORCID: https://orcid.org/0000-0001-5897-4156)
- Hannah Alton (ORCID: https://orcid.org/0009-0009-6606-5476)
- Lei Shi (ORCID: https://orcid.org/0000-0002-4137-096X)
- Emma Gogarnoiu (ORCID: https://orcid.org/0000-0002-9317-2770)
- Zheng‐Xiong Xi (ORCID: https://orcid.org/0000-0001-6482-8104)
- Amy Hauck Newman (ORCID: https://orcid.org/0000-0001-9065-4072)
- Caleb D. Vogt
- Bradley M. Keegan (ORCID: https://orcid.org/0000-0003-0457-4493)
- Emily Linz
- Guo‐Hua Bi
Institutions
- National Institute on Drug Abuse (US)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1111/bph.70021
- Citations
- 4
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 3.64
Funders
- Lundbeckfonden