Metal Concentrations in Blood and Cerebrospinal Fluid of Patients With Arthroplasty Implants
In this cross-sectional study, chronic exposure to arthroplasty implants was associated with corresponding metal accumulation in blood and CSF. Arthroprosthetic cobalt, chromium, titanium, niobium, and zirconium seemed to cross neural barriers and accumulate in CSF. Correlation analyses suggested cobalt-specific transport mechanisms across neural barriers. In view of the neurotoxic effects of cobalt, subsequent studies are needed to determine whether CSF metal concentrations correlate with objective measures of neurotoxic effects and whether this may be of relevance, particularly in patients with new-onset or rapid deterioration of neurological conditions following arthroplasty.
Authors
- Claude Weynandt
- Sascha Treskatsch (ORCID: https://orcid.org/0000-0002-0549-7680)
- Hans‐Dieter Volk (ORCID: https://orcid.org/0000-0002-7743-6668)
- Janosch Schoon (ORCID: https://orcid.org/0000-0003-2337-0795)
- Edda Klotz (ORCID: https://orcid.org/0000-0002-6740-9770)
- Sascha Tafelski (ORCID: https://orcid.org/0000-0002-5623-8400)
- Georg N. Duda (ORCID: https://orcid.org/0000-0001-7605-3908)
- Katrin Huesker
- Alexander B. Kowski (ORCID: https://orcid.org/0000-0002-9963-8113)
- Anastasia Rakow (ORCID: https://orcid.org/0000-0001-6171-8292)
- Carsten Perka
Institutions
- Universitätsmedizin Greifswald (DE)
- Humboldt-Universität zu Berlin (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- CS Diagnostics (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.2281
- Citations
- 4
- Primary Topic
- Orthopaedic implants and arthroplasty
- Type
- article
- Field-Weighted Citation Impact
- 8.03