Integrating network pharmacology and experimental validation to uncover the synergistic effects of Huangqi ()-Ezhu () with 5-fluorouracil in colorectal cancer models.
HQEZ has synergistic effects on the anti-tumor activity of 5-FU in the treatment of colorectal cancer both <i>in vivo</i> and <i>in vitro</i>. The beneficial effect of HQEZ results from the inhibition of the drug sensitivity targets associated with 5-FU. The combination therapy of HQEZ with 5-FU or other chemotherapeutic drugs will also improve the anti-tumor efficacy of chemotherapy.
Authors
- Gang Yin (ORCID: https://orcid.org/0000-0002-0839-242X)
- Shuo Zhang (ORCID: https://orcid.org/0000-0001-8171-2779)
- Tao Jing (ORCID: https://orcid.org/0000-0003-1936-4392)
- Yu Zhang (ORCID: https://orcid.org/0000-0001-8296-154X)
- Tan Xiying
- G U Ruxin
- Sun RuiQian
- Tang Decai
Institutions
- Nanjing University of Chinese Medicine (CN)
- China Pharmaceutical University (CN)
- Nanjing Drum Tower Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-04-01
- DOI
- https://doi.org/10.19852/j.cnki.jtcm.2025.02.004
- Citations
- 1
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 2.38