Electroacupuncture improves cyclophosphamide-induced bladder overactivity by reducing mechanotransduction in the rat urothelium.
These results suggest that EA inhibits bladder sensory function by downregulating the expression of mechanically activated TRPV4 ion channels distributed in bladder urothelial cells, which correspondingly decreases the inward flow of extracellular Ca<sup>2+</sup> and reduces the release of ATP and Ach, thereby attenuating excitatory signals.
Authors
- Lu-Min Liu
- Yuelai Chen (ORCID: https://orcid.org/0000-0001-7246-9420)
- Feng Ji-wei
- Xiaoqian Ge (ORCID: https://orcid.org/0000-0003-1597-6180)
- Jiandang Liu (ORCID: https://orcid.org/0000-0003-3274-834X)
- Wen Li (ORCID: https://orcid.org/0000-0002-8805-2934)
- L. Xu (ORCID: https://orcid.org/0000-0003-2800-1438)
- H U Junwei
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-04-01
- DOI
- https://doi.org/10.19852/j.cnki.jtcm.2025.02.003
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00