Neurotoxicity in Patients With CNS Lymphomas Treated With CAR T-Cell Therapy
Although the rate of neurotoxicity seems acceptable in CNS lymphomas, the risk of unusual prolonged neurologic deterioration is high in patients with grade 3-4 neurotoxicity. Special attention should be given to older patients with cognitive impairment who seem at greater risk of severe forms of neurotoxicity. Larger series are warranted to confirm these results.
Authors
- Madalina Uzunov (ORCID: https://orcid.org/0000-0002-5254-3483)
- Cristina Birzu (ORCID: https://orcid.org/0000-0002-6781-7301)
- Khê Hoang‐Xuan (ORCID: https://orcid.org/0000-0003-4072-1999)
- Sylvain Choquet (ORCID: https://orcid.org/0000-0002-7791-0470)
- Natalia Shor (ORCID: https://orcid.org/0000-0003-0693-1829)
- Carole Soussain (ORCID: https://orcid.org/0000-0002-2479-0348)
- Nuno Miranda (ORCID: https://orcid.org/0000-0001-5175-9947)
- Dimitri Psimaras (ORCID: https://orcid.org/0000-0002-6641-288X)
- Magali Le Garff‐Tavernier (ORCID: https://orcid.org/0000-0002-3131-3240)
- Nicolas Weiss (ORCID: https://orcid.org/0000-0001-5155-196X)
- Laëtitia Souchet
- Agustí Alentorn (ORCID: https://orcid.org/0000-0002-7220-2686)
- Ines Boussen (ORCID: https://orcid.org/0000-0001-7816-0694)
- Delphine Leclercq (ORCID: https://orcid.org/0000-0003-1110-3833)
- Marine Baron (ORCID: https://orcid.org/0000-0003-0212-8684)
- Loïc Le Guennec (ORCID: https://orcid.org/0000-0001-8146-6256)
- Damien Roos‐Weil (ORCID: https://orcid.org/0000-0002-7767-755X)
- Caroline Houillier (ORCID: https://orcid.org/0000-0003-2931-7522)
- Hugo Hernández-Tost
- Valérie Friser
- Véronique Morel (ORCID: https://orcid.org/0000-0003-3678-8672)
- Sirine Mersali
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Pitié-Salpêtrière Hospital (FR)
- Centre de Recherche Saint-Antoine (FR)
- Fondation pour l’innovation en Cadiométabolisme et Nutrition (FR)
- Institut Curie (FR)
Publication Details
- Journal
- Neurology
- Published
- 2025-03-30
- DOI
- https://doi.org/10.1212/wnl.0000000000213501
- Citations
- 7
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 7.32