Canagliflozin ameliorates ferritinophagy in HFpEF rats
Ferritinophagy is activated in HFpEF rats and then inhibited by CANA, leading to HFpEF benefits. The inhibition of ferritinophagy could provide new prospective targets for the prevention and treatment of HFpEF, and provide new ideas for investigating the mechanism of cardiovascular benefit of SGLT2 inhibitors.
Authors
- Sai Ma (ORCID: https://orcid.org/0000-0003-2965-3251)
- Jianlong Zhai
- Lili He (ORCID: https://orcid.org/0000-0002-4118-5377)
- Yifang Guo (ORCID: https://orcid.org/0000-0002-4264-6454)
- Qingjuan Zuo (ORCID: https://orcid.org/0000-0001-6073-3490)
- Tingting Zhang (ORCID: https://orcid.org/0000-0001-9141-2593)
- Guorui Zhang
- Zhongli Wang (ORCID: https://orcid.org/0000-0002-3029-6362)
Institutions
- Hebei General Hospital (CN)
Publication Details
- Journal
- Journal of Geriatric Cardiology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.26599/1671-5411.2025.01.006
- Citations
- 1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.35