Expression of Cancer‐Testis Antigens <scp>MAGE</scp>‐<scp>A1</scp>, <scp>MAGE</scp>‐<scp>A4</scp>, <scp>NY</scp>‐<scp>ESO</scp>‐1 and <scp>PRAME</scp> in Bone and Soft Tissue Sarcomas: The Experience From a Single Center in China
CTA expression in bone and soft tissue sarcomas was correlated with both CTA type and sarcoma subtype, showing relatively high levels of expression in undifferentiated pleomorphic sarcoma (UPS) and osteosarcoma (OS). The poly-expression of MAGE-A4, PRAME, and MAGE-A1 across all subtypes suggests that these antigens may serve as potential targets for sarcoma-specific immunotherapy.
Authors
- Fangcen Liu (ORCID: https://orcid.org/0000-0003-4519-3590)
- Anni Chen (ORCID: https://orcid.org/0009-0003-1131-6115)
- Lixia Yu (ORCID: https://orcid.org/0000-0002-3546-2358)
- Rutian Li (ORCID: https://orcid.org/0000-0003-4800-6156)
- Zijian Wei
- Yuling Qiu (ORCID: https://orcid.org/0000-0003-3314-1072)
- Lin Li (ORCID: https://orcid.org/0000-0002-2158-7096)
- Xiaolu Wang (ORCID: https://orcid.org/0000-0002-4544-8023)
- Chunhua Li (ORCID: https://orcid.org/0000-0002-9947-6855)
- Wang Chun (ORCID: https://orcid.org/0009-0008-5546-7683)
- Ying‐Tzu Yen
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Drum Tower Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1002/cam4.70750
- Citations
- 2
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province for Distinguished Young Scholars