Time‐varying compartmental models capture hours‐scale variation in the elimination kinetics of vancomycin in rats
These results provide further animal-model evidence that the pharmacokinetics of renally cleared drugs can vary significantly over timescales as short as a few hours.
Authors
- Wendy Meiring (ORCID: https://orcid.org/0000-0002-5843-6662)
- Tod E. Kippin (ORCID: https://orcid.org/0000-0003-3216-8863)
- Matthew H. McDonough (ORCID: https://orcid.org/0000-0001-5931-124X)
- Julian Gerson (ORCID: https://orcid.org/0000-0002-5922-4477)
- Kevin W. Plaxco (ORCID: https://orcid.org/0000-0003-4772-8771)
Institutions
- University of California, Santa Barbara (US)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1111/bph.70020
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health