Spatiotemporal profiling of adhesion G protein-coupled receptors in developing mouse and human pancreas reveals a role for GPR56 in islet development
Our data show that aGPCRs are expressed at key stages of human and mouse pancreas endocrine lineage decisions, and analysis of pancreases from Gpr56 knockout mice implicate this aGPCR in the development of a full complement of β-cells.
Authors
- Xianhua Piao (ORCID: https://orcid.org/0000-0001-7540-6767)
- Klaudia Toczyska
- Aileen King (ORCID: https://orcid.org/0000-0001-5759-7985)
- Stefanie Giera (ORCID: https://orcid.org/0000-0002-7414-0562)
- Shanta J. Persaud (ORCID: https://orcid.org/0000-0002-4933-5958)
- Nunzio Guccio
- Oladapo E. Olaniru (ORCID: https://orcid.org/0000-0001-6830-2353)
- Peter M. Jones (ORCID: https://orcid.org/0000-0003-1201-2335)
Institutions
- University of California, San Francisco (US)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1007/s00018-025-05659-z
- Citations
- 1
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 2.01