Exploring the Impact of 731 Immunophenotypes on Alopecia Areata Risk: A Mendelian Randomization Analysis With Plasma Metabolites as Mediators
The analysis substantiates a causal link between HLA DR expression on CD14+ CD16- monocytes and AA, with partial mediation by arachidoylcarnitine (C20) and glycochenodeoxycholate glucuronide. The principal mechanisms by which HLA DR affects AA are yet to be fully elucidated, necessitating further investigations to uncover additional mediators and risk factors.
Authors
- Cuimei Wang
- Hong Liang (ORCID: https://orcid.org/0000-0002-1614-440X)
- Chong Wu (ORCID: https://orcid.org/0009-0000-8801-9344)
Institutions
- Fifth Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Journal of Craniofacial Surgery
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1097/scs.0000000000011291
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00