An Efficient Synthesis of Quinoline Derivatives using Polymer-Supported Sulphonic Acid via Friendlier Pathway: A Green Protocol

An efficient method for synthesizing quinoline derivatives (3a-l) was reported using polyethylene glycol-based sulphonic acid (PEG-SA) and polystyrene-supported polyethylene glycol-based sulphonic acid (PS-PEG-SA) as recyclable catalysts via a friendlier reaction pathway. This strategy is more environmentally sustainable than traditional methods for synthesizing quinoline derivatives, yielding favorable yields and facilitating ease of operation under mild reaction conditions. In presence of PEG-SA/PS-PEG-SA catalyst, carbonyl compounds with an active α-methylene group were added to 2-aminophenyl ketones/aldehydes to produce substituted quinoline compounds. Adhering to green chemistry principles, this strategy provides a productive way to synthesize functionally useful quinoline derivatives, raising the hope for the breakthrough in the pharmaceutical and material sciences.