Influence of Maternal Alpha-Lipoic Acid Supplementation on Postpartum Body Weight and Metabolic Health in Rats with Obesity

We examined the influence of dietary α-lipoic acid (LA; R enantiomer) supplementation in obese-complicated pregnancies on maternal postpartum body weight and metabolic health. Forty-eight female Sprague-Dawley rats were randomized into three dietary groups throughout pre-pregnancy, gestation, and lactation: (i) a low-calorie control diet (CON); (ii) a high calorie obesity-inducing diet (HC); or (iii) the HC diet with 0.25% LA (HC+LA). Following offspring weaning, all mothers were switched to the CON diet for a postpartum period of 140 days to assess maternal body weight and markers of metabolic health. HC-fed mothers showed excessive (<i>p</i> < 0.05) gestational weight gain (GWG), higher (<i>p</i> < 0.05) postpartum body weight, reduced (<i>p</i> < 0.05) glycemic control (lower glucose:insulin ratio) and higher (<i>p</i> = 0.06) hepatic cholesterol concentration versus CON mothers. In contrast, HC+LA mothers demonstrated lower (<i>p</i> < 0.05) body weight throughout the experimental period compared with HC mothers, primarily due to a marked reduction in GWG. Although LA did not protect (<i>p</i> > 0.05) against reduced glycemic control, it did alter several aspects of lipid metabolism including reduced serum HDL-C and a lower concentration of hepatic cholesterol which was mediated partly through a reduction in low-density lipoprotein receptor expression. We conclude that maternal obesity during pregnancy leads to a longer-term detrimental impact on weight gain and glycemic control, even after switching to a low-calorie postpartum diet. Maternal LA supplementation may be able to partially offset these effects, likely by protecting against excessive GWG during pregnancy. However, further work is required to determine the consequences of reduced serum HDL-C in LA-supplemented mothers.