Cilnidipine: An L- and N-Type Blocker of Calcium Channels Ameliorating Renal Damage in Experimental Hypertensive Rats

These results showed that in hypertensive experimental rats, cilnidipine, apart from its hypotensive actions, decreases proteinuria and urinary creatinine and Ang II levels. These actions of cilnidipine may be because of blocking N-type calcium channels. Therefore, cilnidipine dual L/N type CCB may act as a renoprotective drug and decrease glomerular damage. Further mechanistic studies using selective N-type channel blockers or knockout mice are needed to prove the findings.