Dose Constraints in Carbon-Ion Radiation Therapy to Minimize the Risk of Pectoral Myositis
This study is the first to evaluate pectoral myositis after C-ion RT for breast cancer. The findings suggest that high RBE-weighted doses in small muscle volumes increase the risk of myositis, while LET is not a significant factor. Establishing dose constraints for the pectoralis major muscle is crucial to minimize radiation-induced toxicity. Further studies with larger cohorts are needed to validate these results.
Authors
- Tetsuro Sayama (ORCID: https://orcid.org/0000-0001-9885-7501)
- Noriyuki Okonogi (ORCID: https://orcid.org/0000-0002-9486-1922)
- Kumiko Karasawa (ORCID: https://orcid.org/0000-0003-1628-8662)
- Hitoshi Ishikawa (ORCID: https://orcid.org/0000-0002-0046-9787)
- Kazutoshi Murata (ORCID: https://orcid.org/0000-0003-1836-6353)
- Ikumi Furuichi
Institutions
- Japan Proton Accelerator Research Complex (JP)
- Juntendo University (JP)
- National Institutes for Quantum Science and Technology (JP)
- Kawasaki Hospital (JP)
Publication Details
- Journal
- International Journal of Particle Therapy
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1016/j.ijpt.2025.100746
- Primary Topic
- Management of metastatic bone disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Science and Technology Agency