Genetic and epigenetic regulation of Treg cell fitness by autism-related chromatin remodeler CHD8
Our findings suggest that CHD8 plays an important role in maintaining Treg fitness through genetic and epigenetic mechanisms to control autoimmunity, which may have important implications in immune changes in autism.
Authors
- Mario Pujato (ORCID: https://orcid.org/0000-0002-2415-3111)
- Fukun Guo (ORCID: https://orcid.org/0000-0002-8820-7633)
- Jun‐Qi Yang (ORCID: https://orcid.org/0000-0002-4510-8117)
- Manohar Kolla (ORCID: https://orcid.org/0000-0002-7095-8877)
- Mingjun Cai (ORCID: https://orcid.org/0000-0001-5677-5372)
- Ramesh C. Nayak (ORCID: https://orcid.org/0000-0002-3206-8152)
- Chen Wang (ORCID: https://orcid.org/0000-0002-2191-3891)
- Yi Zheng
- Q. Richard Lu (ORCID: https://orcid.org/0000-0001-6846-9014)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- University of Cincinnati (US)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1186/s11658-025-00711-z
- Citations
- 4
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- National Cancer Institute