Vildagliptin attenuates doxorubicin-induced hepatotoxicity via activating Nrf2/HO-1 and SIRT1 and suppressing NF-κB signals in rats

Our findings suggest that vildagliptin improved hepatocellular architecture and reduced hepatic oxidative injury, inflammation, and apoptosis associated with DOX treatment.

Authors

Institutions

Publication Details

Journal
Immunopharmacology and Immunotoxicology
Published
2025-03-27
DOI
https://doi.org/10.1080/08923973.2025.2482863
Citations
2
Primary Topic
Sirtuins and Resveratrol in Medicine
Type
article
Field-Weighted Citation Impact
2.45
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Vildagliptin attenuates doxorubicin-induced hepatotoxicity via activating Nrf2/HO-1 and SIRT1 and suppressing NF-κB signals in rats

Emad H. M. Hassanein, Heba M. Mahmoud, Marwa M. Khalaf
2 citations
Immunopharmacology and Immunotoxicology
Sirtuins and Resveratrol in Medicine
2.45
article

Vildagliptin attenuates doxorubicin-induced hepatotoxicity via activating Nrf2/HO-1 and SIRT1 and suppressing NF-κB signals in rats

Emad H. M. Hassanein, Heba M. Mahmoud, Marwa M. Khalaf
article en
2 citations

Abstract

Our findings suggest that vildagliptin improved hepatocellular architecture and reduced hepatic oxidative injury, inflammation, and apoptosis associated with DOX treatment.

Immunopharmacology and ImmunotoxicologyVol. 47(3)
Beni-Suef University (EG), Al-Azhar University (ID)
Zero hunger
Openalex Percentile: Top 13%
Sirtuins and Resveratrol in Medicine
2.45
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.