Hypericin impedes M2 macrophage polarization and protects against Hepatocellular carcinoma
Hyp impedes the growth, proliferation, invasion and migration of HCC by inhibiting M2 macrophages polarization via the PI3K/AKT signaling pathway, our data demonstrate that hypericin may be a promising candidate for HCC treatment.
Authors
- Xiaohe Xiao (ORCID: https://orcid.org/0000-0002-2836-2738)
- Simin Chen (ORCID: https://orcid.org/0009-0006-2807-0109)
- Ang Huang (ORCID: https://orcid.org/0000-0001-8876-9903)
- Chengwei Li (ORCID: https://orcid.org/0000-0002-5883-4812)
- Xianling Wang (ORCID: https://orcid.org/0000-0001-7350-4101)
- Qing Yao (ORCID: https://orcid.org/0009-0002-0015-0407)
- Xiaoyan Zhan (ORCID: https://orcid.org/0000-0002-2446-5967)
- X. Y. Wen
- Congyang Zheng
- Zhaofang Bai
Institutions
- Chinese PLA General Hospital (CN)
- First Affiliated Hospital of Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Molecular Immunology
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1016/j.molimm.2025.03.012
- Citations
- 2
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality
- Beijing Nova Program