Hypolipidemic Activity of Saaranai Chooranam Against Atherogenic Diet Induced Hyperlipidemia in Experimental Rats in the Management of Raththa Kothippu (Systemic Hypertension)

In worldwide Siddha system of medicine nowadays become most important medicine, it has fewer side effects in chronic usage. Therefore, in medicines of Siddha system should emphasis their Indications, Contraindications and cautions. The trial drug Saaranai chooranam has been mentioned in siddha literature of “Agasthiyar erandayiram – Part-III” for the management of Raththa kothippu (Systemic hypertension). Primary objective of study to evaluate the Hypolipidemic activity of saaranai chooranamagainst atherogenic diet induced hyperlipidemia in experimental rats. This Observational in vivo study carried out Arulmigu Kalasalingam College of Pharmacy, Tamil Nadu, India. The trial drug contains equal ratio of Saaranai Root and Inthuppu, with adjuvant Ghee or Jagarry. All animals starved for 18 hours and provided water ad libitumbefore the experiment. The animals were divided into five groups of six rats each. Group I served as normal control administered with 2% Carboxy Methyl Cellulose only, Group II served as hyperlipidemic control rats received atherogenic diet, Group III and IV served as test groups received Saaranai Chooranam 200mg/kg and Saaranai Chooranam 400mg/kg respectively. Group V served as Atorvastatin (10mg/kg/day) considered as standard. All the groups except the normal control group administered received atherogenic diet After inducing the hyperlipidemia, the respective treatment was continued for 7 days. Animals were given standard pellet diet and water ad libitum. The next day after the completion of experimental study, the blood was taken from the rats, Liver lipid extraction, Biochemical analysis, Histopathology. The data were statistically analyzed by one-way ANOVA followed by Dennett’s t-test, and value P < 0.05 was considered to be significant. The results obtained from the pharmacological screening have led to the conclusions that, Saaranai chooranam has significant antihyperlipidemic activity. Hence it can be exploited as antihyperlipidemic therapeutic agent or adjuvant in existing therapy for the treatment of hyperlipidemia. Keywords: Saaranai chooranam, Raththa kothippu, Hyperlipidemia, Akasthiyar erandayirum.