Silencing miR-1291-LEFTY2 axis diminishes the myofibroblast activities and reactive oxygen species generation of fibrotic buccal mucosal fibroblasts
Our findings demonstrated that miR-1291 may promote fibrosis in OSF by suppressing LEFTY2 expression to increase myofibroblast activation via regulation of ROS accumulation and TGF-β/Smad signaling.
Authors
- Pei‐Ling Hsieh (ORCID: https://orcid.org/0000-0002-4190-6795)
- Chang-Yi Tsai
- Shih‐Min Wang (ORCID: https://orcid.org/0000-0002-4890-5656)
- Yi-Wen Liao
- Ming‐Yung Chou
- Cheng-Chia Yu
Institutions
- Chang Gung University of Science and Technology (TW)
- China Medical University (TW)
- Chung Shan Medical University Hospital (TW)
- Changhua Christian Hospital (TW)
- Chung Shan Medical University (TW)
Publication Details
- Journal
- Journal of Dental Sciences
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1016/j.jds.2025.03.019
- Citations
- 1
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.94