5-FU@HFn combined with decitabine induces pyroptosis and enhances antitumor immunotherapy for chronic myeloid leukemia
The innovative therapeutic strategy, combining 5-FU@HFn nanoparticles with low-dose DAC, effectively induces caspase-3/GSDME-mediated pyroptosis and activates antitumor immunity for CML. This approach offers a potential alternative for patients resistant or intolerant to TKIs.
Authors
- Guoyun Jiang
- Kelong Fan (ORCID: https://orcid.org/0000-0001-6285-1933)
- Wenyao Zhang (ORCID: https://orcid.org/0000-0001-7080-9604)
- Lujia Tang
- Zuowei Yuan
- Qian Liang
- Ying Yuan (ORCID: https://orcid.org/0000-0003-2440-4053)
- Wenli Feng (ORCID: https://orcid.org/0000-0003-0889-8348)
- Yaxin Hou (ORCID: https://orcid.org/0000-0002-1330-6506)
Institutions
- Chinese Academy of Sciences (CN)
- Henan Academy of Sciences (CN)
- Institute of Biophysics (CN)
- Shandong Provincial Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Children's Hospital of Chongqing Medical University (CN)
- First People's Hospital of Chongqing (CN)
- Shandong First Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1186/s12951-025-03335-9
- Citations
- 5
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province