Enantioselective Spirocyclization of Pd‐Enolates and Isocyanates
An enantioselective cyclization of Pd-enolates and isocyanates to form spirocyclic γ-lactams is reported. This reaction proceeds under mild reaction conditions and utilizes a novel Meldrum's acid derivative to achieve catalyst turnover, delivering enantioenriched products in up to 97% yield and 96% ee. Preliminary mechanistic investigations suggest that the reaction may proceed via the formation of higher-order species.
Authors
- Melinda Chan (ORCID: https://orcid.org/0000-0002-2495-0110)
- Brian M. Stoltz (ORCID: https://orcid.org/0000-0001-9837-1528)
- Kaylin N. Flesch (ORCID: https://orcid.org/0000-0002-8582-2614)
- Jay P. Barbor (ORCID: https://orcid.org/0000-0003-2787-4923)
- H Ang
Institutions
- California Institute of Technology (US)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1002/anie.202502583
- Citations
- 2
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.87