Maternal allostatic load in pregnancy is prospectively associated with child adiposity and metabolic function across infancy and early childhood.
Our findings suggest that exposure to a higher biological stress milieu during prenatal development predisposes towards elevated early life adiposity and insulin resistance in early childhood, a proximate cause of type 2 diabetes and cardiometabolic disease. Collectively, these results provide evidence that a multi-systems approach to quantify early life exposures is useful in prospectively predicting variation in childhood adiposity and metabolic function.
Authors
- Sonja Entringer (ORCID: https://orcid.org/0000-0002-9926-7076)
- Wen‐Pin Chen (ORCID: https://orcid.org/0000-0002-0143-5642)
- P.D. Wadhwa
- Lauren E. Gyllenhammer (ORCID: https://orcid.org/0000-0003-4338-8984)
- J.M. Rasmussen
- Daniel L. Gillen (ORCID: https://orcid.org/0000-0003-0200-1771)
- KL Lindsay
- Kristen E. Boyle (ORCID: https://orcid.org/0000-0001-9689-3322)
Institutions
- University of California, Irvine (US)
- Humboldt-Universität zu Berlin (DE)
- UC Irvine Health (US)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Irvine University (US)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- Psychoneuroendocrinology
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1016/j.psyneuen.2025.107450
- Citations
- 3
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 10.48
Funders
- National Institute of Mental Health and Neurosciences
- National Institutes of Health
- National Institute of Child Health and Human Development
- Center for Scientific Review
- National Center for Advancing Translational Sciences