HIF Drives Expression of Immunogenic Endogenous Retroviruses in Cancer

Major Finding: HIF induces expression of relatively intact endogenous retroviruses in clear cell renal cell carcinoma.Concept: Translation and antigen presentation of endogenous retroviruses elicits antigen-specific T-cell responses. Impact: Endogenous retrovirus expression can be induced therapeutically and may augment immunotherapy response.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-034
Primary Topic
Cancer Research and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

HIF Drives Expression of Immunogenic Endogenous Retroviruses in Cancer

Cancer Discovery
Cancer Research and Treatments
article

HIF Drives Expression of Immunogenic Endogenous Retroviruses in Cancer

article en

Abstract

Major Finding: HIF induces expression of relatively intact endogenous retroviruses in clear cell renal cell carcinoma.Concept: Translation and antigen presentation of endogenous retroviruses elicits antigen-specific T-cell responses. Impact: Endogenous retrovirus expression can be induced therapeutically and may augment immunotherapy response.

Cancer Discovery
Openalex Percentile: Top 94%
Cancer Research and Treatments
DOISourceOpenAlex
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HIF Drives Expression of Immunogenic Endogenous Retroviruses in Cancer · Cancer Discovery (2025) | TGRS Research Map | TGRS