Darier's Disease: The Benefits of Dermoscopy

Darier disease is a rare genodermatosis transmitted in autosomal dominance, with more or less complete penetrance and variable expressivity within each generation. It combines mainly follicular papulokeratotic lesions, predominantly in seborrheic areas, with acral involvement and highly suggestive nail lesions. The disease has a chronic course, marked by bacterial or viral superinfections. Knowledge of this disease has advanced considerably in recent years, with the gene responsible for it now located on the long arm of chromosome 12. Dermoscopic aspects of this dermatosis are poorly reported in the literature. We describe the clinical and dermoscopic analysis of lesions in a patient treated in our clinic for Darier's disease. Dermoscopic signs can help guide the diagnosis of Darier's disease.