Mac-1 blockade impedes adhesion-dependent neutrophil extracellular trap formation and ameliorates lung injury in LPS-induced sepsis
Our findings offer insights into the critical role of EC-neutrophil direct contact in NET formation during sepsis and propose Mac-1 as a potential therapeutic target.
Authors
- Tiantian Hong
- Jinhua Fang (ORCID: https://orcid.org/0000-0003-0478-9355)
- Peimin Liu (ORCID: https://orcid.org/0009-0005-2069-8391)
- Ying Fang
- Junxian Yang
- Hongguang Ding (ORCID: https://orcid.org/0000-0003-4420-5684)
- Jiangguo Lin (ORCID: https://orcid.org/0000-0002-1373-3268)
- Xin Li (ORCID: https://orcid.org/0000-0003-0958-1078)
- Peng Liu (ORCID: https://orcid.org/0000-0002-1667-6617)
- Zhiwei Wu (ORCID: https://orcid.org/0000-0003-4721-1617)
- Z. Li (ORCID: https://orcid.org/0000-0002-1232-2803)
- Jiaqi Huang (ORCID: https://orcid.org/0000-0002-9006-2453)
- Jianhua Wu (ORCID: https://orcid.org/0000-0002-1057-7220)
- Shiying Zhang
Institutions
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1548913
- Citations
- 6
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 4.78