Exploring the therapeutic mechanism of curcumin in spinal cord injury treatment based on network pharmacology, molecular dynamics simulation, and experimental validation
Curcumin exerts its effects on SCI through multiple targets and pathways. Its specific mechanisms involve the inhibition of inflammation, prevention of apoptosis and ferroptosis, and promotion of neuronal repair. MMP9 may be a key target mediating curcumin's protective effects against SCI. These findings provide scientific evidence for further research and development of drugs.
Authors
- Rizhao Pang
- Yunyun Wang (ORCID: https://orcid.org/0000-0001-8421-8370)
- Yang Luo (ORCID: https://orcid.org/0000-0001-7385-6166)
- Xiaoming Hu (ORCID: https://orcid.org/0000-0002-5857-6243)
- Hua Xiao (ORCID: https://orcid.org/0000-0001-6100-0969)
- Yongzhi He (ORCID: https://orcid.org/0000-0002-3959-3849)
- Lijuan Ding (ORCID: https://orcid.org/0000-0002-9156-9328)
- Wenchun Wang
Institutions
- North Sichuan Medical University (CN)
- Guangzhou University of Chinese Medicine (CN)
- Chengdu Medical College (CN)
- Nanchong Central Hospital (CN)
- Southwest Jiaotong University (CN)
Publication Details
- Journal
- Frontiers in Chemistry
- Published
- 2025-03-28
- DOI
- https://doi.org/10.3389/fchem.2025.1568551
- Citations
- 5
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 4.55