Unraveling the Mechanism of Tangmaikang Granules in Treating Diabetic Kidney Disease Based On UPLC-MS/MS, Network Pharmacology, Molecular Docking, Molecular Dynamics Simulations, and Experimental Validation
TMK granules target DKD through a multi-component, multi-target strategy, effectively mitigating oxidative stress and suppressing inflammatory and apoptotic pathways. This study integrates advanced computational and experimental methods, demonstrating TMK's unique therapeutic potential and providing a robust foundation for its clinical application in DKD management.
Authors
- Shuqin Liu (ORCID: https://orcid.org/0009-0006-6025-6931)
- Xinzhu Yuan (ORCID: https://orcid.org/0009-0001-2331-0824)
- Changwei Lin (ORCID: https://orcid.org/0000-0003-1676-0912)
- Xisheng Xie (ORCID: https://orcid.org/0000-0002-2268-7662)
- Ying Zhang (ORCID: https://orcid.org/0000-0002-3672-3345)
- Zhixin Wang (ORCID: https://orcid.org/0000-0001-7255-6049)
- Huaming Xian
Institutions
- North Sichuan Medical University (CN)
- Capital Medical University (CN)
- Beijing Anzhen Hospital (CN)
- Nanchong Central Hospital (CN)
Publication Details
- Journal
- Current Pharmaceutical Biotechnology
- Published
- 2025-03-28
- DOI
- https://doi.org/10.2174/0113892010369197250321083806
- Primary Topic
- Glutathione Transferases and Polymorphisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00