Paeonol Inhibits the MAPK Signaling Pathway by Targeting SIRT1 inAGE-Induced HUVECs Injury
This research revealed that paeonol inhibited the activation of p38 and ERK within the MAPK signaling pathway. Moreover, the regulatory influence of paeonol over p38 and ERK was compromised subsequent to the silencing of SIRT1, indicating a SIRT1-dependent suppressive action of paeonol on the MAPK pathway. The potential therapeutic utility of SIRT1 in mitigating diabetic endothelial impairment and its concomitant cardiovascular ramifications is underscored by these findings.
Authors
- Dingkun Liu (ORCID: https://orcid.org/0000-0002-1262-8458)
- Yulin Mo
- Liang Feng (ORCID: https://orcid.org/0000-0003-4807-7480)
- Hongrui Gao
- Xiaochun Wu (ORCID: https://orcid.org/0000-0002-2054-5329)
- Minghua Zhang (ORCID: https://orcid.org/0000-0001-7299-8752)
- Xiaobin Jia (ORCID: https://orcid.org/0009-0009-5536-5166)
Institutions
- China Pharmaceutical University (CN)
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2025-03-27
- DOI
- https://doi.org/10.2174/0113862073359192250311081427
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00