Exploring Mechanisms of Ephx2 in Treating Atherosclerosis Using Independent Cascade Model and Adverse Outcome Pathways

By defining the AS network and corresponding RD, this study elucidated potential mechanisms by which Ephx2 affects AS through specific KEGG pathways, AOPs, and target genes. These findings enhanced the understanding of AS pathogenesis and highlighted potential targets like Mapk3 for developing therapeutic strategies in AS prevention and treatment.

Authors

Wei Pang (ORCID: https://orcid.org/0000-0001-6328-7043)
C. Zhang
Yong Chen (ORCID: https://orcid.org/0000-0002-3520-1991)
Yong Dai (ORCID: https://orcid.org/0000-0003-1260-4234)
Bo Cao (ORCID: https://orcid.org/0000-0002-9324-261X)
Jinbing An (ORCID: https://orcid.org/0000-0002-2784-1390)

Institutions

Peking University (CN)
Jiangxi Normal University (CN)

Publication Details

Journal: Combinatorial Chemistry & High Throughput Screening
Published: 2025-03-27
DOI: https://doi.org/10.2174/0113862073345542250220051427
Primary Topic: Eicosanoids and Hypertension Pharmacology
Type: article
Field-Weighted Citation Impact: 0.00

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article

Exploring Mechanisms of Ephx2 in Treating Atherosclerosis Using Independent Cascade Model and Adverse Outcome Pathways

Wei Pang, C. Zhang, Yong Chen, Yong Dai et al.

Mar 27, 2025

Combinatorial Chemistry & High Throughput Screening

Eicosanoids and Hypertension Pharmacology

article

Exploring Mechanisms of Ephx2 in Treating Atherosclerosis Using Independent Cascade Model and Adverse Outcome Pathways

Wei Pang, C. Zhang, Yong Chen, Yong Dai, Bo Cao, Jinbing An

March 27, 2025article en

Abstract

By defining the AS network and corresponding RD, this study elucidated potential mechanisms by which Ephx2 affects AS through specific KEGG pathways, AOPs, and target genes. These findings enhanced the understanding of AS pathogenesis and highlighted potential targets like Mapk3 for developing therapeutic strategies in AS prevention and treatment.

Combinatorial Chemistry & High Throughput ScreeningVol. 28

Peking University (CN), Jiangxi Normal University (CN)

Good health and well-being

Openalex Percentile: Top 93%

Eicosanoids and Hypertension Pharmacology

DOI Source OpenAlex

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Exploring Mechanisms of Ephx2 in Treating Atherosclerosis Using Independent Cascade Model and Adverse Outcome Pathways — Wei Pang, C. Zhang, et al. · Combinatorial Chemistry & High Throughput Screening (2025) | TGRS Research Map | TGRS