Combining serum biomarkers and MRI radiomics to predict treatment outcome after thermal ablation in hepatocellular carcinoma

The integrated clinical-radiological-radiomics model showed excellent predictive performance for the prognosis of HCC patients undergoing RFA, surpassing individual models. Key predictors included serum AFP, AFP-L3 levels, intratumoral hemorrhage, and peritumoral low signal intensity. This multimodal approach offers a promising tool for individualized prognostic assessment and improved clinical decision-making.