Qingkailing injection induces pseudo-allergic reactions via the MRGPRX2 pathway
We found that QKLI induced pseudoanaphylaxis via an IgE-independent response in guinea pigs and through the MRGPRX2 pathway in human LAD2 cells. Among these, the main ingredients causing pseudoallergic reactions in QKLI were BA and GE. Our research contributes to a better understanding of the mechanisms underlying drug hypersensitivity reactions (DHRs).
Authors
- Yuxin Zhang (ORCID: https://orcid.org/0000-0003-4698-5645)
Institutions
- Nanjing University of Chinese Medicine (CN)
- China Pharmaceutical University (CN)
Publication Details
- Journal
- American Journal of Translational Research
- Published
- 2025-01-01
- DOI
- https://doi.org/10.62347/mfbu4210
- Citations
- 3
- Primary Topic
- Medicinal Plant Pharmacodynamics Research
- Type
- article
- Field-Weighted Citation Impact
- 4.67
Funders
- National Natural Science Foundation of China