A New Score in Contrast Induced Nephropathy

Abstract Background The haemoglobin, albumin, lymphocyte, and platelet (HALP) score is a new score and provides information regarding the patient's health, nutritional status, and inflammatory response. No study has assessed the relationship between HALP score and contrast induced nephropathy (CIN) in patients with stable angina pectoris. This study aimed to investigate the association between the HALP score and CIN in patients with stable angina pectoris undergoing coronary angiography (CAG). Methods A total of 1140 consecutive patients with stable angina pectoris who underwent CAG were included in this retrospective study. CIN was defined as a ≥ 25% increase in serum creatinine compared with baseline value within 72 h of CAG. Patients were divided into two groups as those who developed CIN and those who did not develop CIN. The groups were compared in terms of hemogram parameters, simple biochemical parameters and HALP score. Results Age, post-procedural creatinine, platelet, white blood cell count and the amount of opaque used were found to be higher, whereas high-density lipoprotein, albumin, lymphocyte and HALP score were found to be lower in the CIN group than non-CIN group. Multivariate regression analysis showed that the amount of opaque used and HALP score independently predicted the development of CIN. Conclusion In the present study, HALP score was found to independently predict the likelihood of developing CIN, a complication with high mortality after angiography. Therefore, patients at high risk of CIN may be identified in advance with the HALP score and the development of CIN can be prevented by appropriate pre-medication.