Evaluation of cerebrospinal fluid treponema pallidum particle agglutination assay titer for neurosyphilis diagnosis among HIV-negative syphilis patients
This study revealed that a CSF-TPPA titer ≥ 1:320 can be used as a highly sensitive and practical marker for diagnosing neurosyphilis. A titer threshold of ≥1:320 could offer a reliable alternative in cases when CSF-VDRL is negative.
Authors
- Fuquan Long (ORCID: https://orcid.org/0000-0001-7355-503X)
- Liyan Ni
- Tengfei Qi (ORCID: https://orcid.org/0000-0002-0979-4260)
- Pingyu Zhou (ORCID: https://orcid.org/0000-0002-9623-4201)
- Wei Zhao (ORCID: https://orcid.org/0000-0002-9998-1544)
- Yuanyuan Cheng (ORCID: https://orcid.org/0000-0002-3851-4512)
- Danyang Zou (ORCID: https://orcid.org/0000-0002-7353-6741)
- Xin Gu (ORCID: https://orcid.org/0000-0001-7274-1754)
- Zhifang Guan
- Lin Zhu (ORCID: https://orcid.org/0000-0002-7995-0089)
- Mei Shi
Institutions
- Tongji University (CN)
- Shanghai Skin Disease Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1572137
- Citations
- 4
- Primary Topic
- Syphilis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.66