Vascular smooth muscle cell-derived SO2 sulphenylated interferon regulatory factor 1 to inhibit VSMC senescence
Reduction of the endogenous SO<sub>2</sub>/AAT1 pathway played a crucial role in driving VSMC senescence. Endogenous SO<sub>2</sub> counteracted VSMC senescence and vascular aging via the sulphenylation of IRF1 at C83.
Authors
- Hongfang Jin (ORCID: https://orcid.org/0000-0002-1606-8988)
- Xiao‐Qi Yu (ORCID: https://orcid.org/0000-0003-1719-6137)
- Shuang Ge (ORCID: https://orcid.org/0000-0002-3814-7820)
- Bingquan Qiu
- Yaqian Huang (ORCID: https://orcid.org/0000-0001-8346-3809)
- Zhengyu Yu (ORCID: https://orcid.org/0000-0002-8888-4570)
- Shangyue Zhang (ORCID: https://orcid.org/0000-0002-6741-3577)
- Kun Li (ORCID: https://orcid.org/0000-0002-8788-1036)
- Deqing Wang (ORCID: https://orcid.org/0000-0003-1553-7786)
- Chaoshu Tang
- Junbao Du
Institutions
- Peking University (CN)
- Sichuan University (CN)
- Chinese PLA General Hospital (CN)
- West China Hospital of Sichuan University (CN)
- Peking University First Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-28
- DOI
- https://doi.org/10.3389/fphar.2025.1516885
- Citations
- 1
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.80