Auditory evoked delta brushes involve stimulus-specific cortical networks in preterm infants
During the third trimester of gestation in humans, the auditory cortex displays spontaneous and auditory-evoked EEG patterns of intermittent local oscillatory activity nested in delta waves - delta brushes (DBs). To test whether the spatiotemporal dynamics of evoked DBs depends on stimulus type, we studied auditory evoked responses (AERs) to voice and "click" using 32-electrode EEG in 30 healthy neonates aged 30 to 38 post-menstrual weeks. Both stimuli elicited two peaks at approximately 250 ms and 600 ms, the second corresponding to the first principal components of the AER and the evoked DB. The DB showed stimulus-specific topography, temporal posterior and mid-temporal for "click", and mid-temporal and pre-central inferior for voice, and contained theta to gamma oscillations more widespread for the "click"response. Gamma oscillations increased with age. AERs predominated on the right but shifted toward the left with age for voice response. Auditory evoked DBs may therefore underlie specific auditory processing during fetal development.
Authors
- Anna Kamińska (ORCID: https://orcid.org/0000-0003-3805-6651)
- Lisa Ouss (ORCID: https://orcid.org/0000-0002-5266-9836)
- Mathieu Kuchenbuch (ORCID: https://orcid.org/0000-0002-5944-2204)
- Dorothée Arzounian (ORCID: https://orcid.org/0000-0003-1520-0227)
- Victor Delattre (ORCID: https://orcid.org/0000-0002-9952-4730)
- Roustem Khazipov (ORCID: https://orcid.org/0000-0002-6763-2841)
- Anne Boissel (ORCID: https://orcid.org/0000-0002-1113-1378)
- Lucie Hertz‐Pannier (ORCID: https://orcid.org/0000-0003-4952-7009)
- Catherine Chiron (ORCID: https://orcid.org/0000-0002-9096-1694)
- Yves Denoyer (ORCID: https://orcid.org/0000-0002-1395-7341)
- Jessica Dubois (ORCID: https://orcid.org/0000-0003-4865-8111)
- Mostafa Mokhtari (ORCID: https://orcid.org/0000-0001-5019-9167)
- Fabrice Wendling (ORCID: https://orcid.org/0000-0003-2428-9665)
- Antoine Manresa
- Shushanik Hovhannisyan
- Jean‐François Magny
- Jacques Laschet
Institutions
- Hôpital Necker-Enfants Malades (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Aix-Marseille Université (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris Nanterre (FR)
- Institut Necker Enfants Malades (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre Hospitalier de Bretagne Sud (FR)
- Centre Hospitalier Régional et Universitaire de Nancy (FR)
- Normandie Université (FR)
- Institut de Neurobiologie de la Méditerranée (FR)
- Centre de Recherche sur les Fonctionnements et Dysfonctionnements Psychologiques (FR)
- Hôpital Saint-Louis (FR)
- Bicêtre Hospital (FR)
- NeuroDiderot (FR)
- Université de Rouen Normandie (FR)
- Université de Lorraine (FR)
Publication Details
- Journal
- iScience
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1016/j.isci.2025.112313
- Citations
- 1
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 3.49