Light-triggered release of lenalidomide with fluorescent indication for inhibition of COX-2 enzyme activity in cancer cells
In this work, we have developed a Sanger's reagent-based photocage, LNDA-NBD-Sanger, which releases the caged COX-2 inhibitor, lenalidomide (LNDA), under 400 nm UV irradiation while producing a fluorescent signal from the activated nitrobenzoxadiazole (NBD) derivative, realizing the monitoring of LNDA release in cancer cells and light-controlled anti-cancer therapy.
Authors
- Long Jiang (ORCID: https://orcid.org/0000-0002-1781-134X)
- Sheng Lu (ORCID: https://orcid.org/0000-0003-0481-8531)
- Fang Wang (ORCID: https://orcid.org/0000-0002-4781-8673)
- Ming Liu (ORCID: https://orcid.org/0000-0002-4770-4449)
- Xiaoqiang Chen (ORCID: https://orcid.org/0000-0003-2493-2067)
- Yajing Li (ORCID: https://orcid.org/0000-0002-7118-4658)
Institutions
- Nanjing Tech University (CN)
- Shanghai Innovative Research Center of Traditional Chinese Medicine (CN)
- The Synergetic Innovation Center for Advanced Materials (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc00695c
- Citations
- 2
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 1.87