Design of a peptide-based vaccine against human respiratory syncytial virus using a reverse vaccinology approach: evaluation of immunogenicity, antigenicity, allergenicity, and toxicity
This study presents a promising peptide-based vaccine candidate against hRSV that can effectively engage the immune system, showing strong immunogenicity and antigenicity. Future <i>in vitro</i> and <i>in vivo</i> studies are essential to evaluate the ability of the multi-epitope vaccine candidate to stimulate both humoral and cell-mediated immune responses and to assess its efficacy and safety profile.
Authors
- Intikhab Álam (ORCID: https://orcid.org/0000-0001-5306-847X)
- Fahad M. Aldakheel (ORCID: https://orcid.org/0000-0001-8047-8650)
- Wael Alturaiki (ORCID: https://orcid.org/0000-0002-6947-7582)
- Afaque A. Momin (ORCID: https://orcid.org/0000-0002-5058-9445)
- Maaweya Awadalla (ORCID: https://orcid.org/0000-0002-1270-2216)
- Bandar Alosaimi (ORCID: https://orcid.org/0000-0003-4719-2655)
- Hadeel Alnajran
Institutions
- Majmaah University (SA)
- King Fahd Medical City (SA)
- King Saud University (SA)
- King Abdullah University of Science and Technology (SA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1546254
- Citations
- 8
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 10.83
Funders
- King Saud University